ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

309628

Symbol:

Wdr46

Full Name:

WD repeat domain 46

Alias:

Bing4|MGC94931

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

20p12

Physical Location:

5089610-5097382 on NC_005119.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 9277 Symbol (Name): WDR46 (WD repeat domain 46)

Ortholog Status:

The human GeneID 9277 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Wdr46
Fold Change:		-1.2
P Value:		0.006
Note:		Differential expression between ethanol and saccharin groups in amygdala

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_212491.2	NP_997656.1	NC_005119.2 range: 5089610..5097382, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000139	Golgi membrane	Cellular Component	IEA
GO:0005884	actin filament	Cellular Component	IEA
GO:0016272	prefoldin complex	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0005581	collagen	Cellular Component	IEA
GO:0005615	extracellular space	Cellular Component	IEA
GO:0005622	intracellular	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	ISS
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005794	Golgi apparatus	Cellular Component	IEA
GO:0016605	PML body	Cellular Component	IEA
GO:0000792	heterochromatin	Cellular Component	IEA
GO:0001891	phagocytic cup	Cellular Component	IEA
GO:0042612	MHC class I protein complex	Cellular Component	IEA
GO:0042613	MHC class II protein complex	Cellular Component	IEA
GO:0001726	ruffle	Cellular Component	IEA
GO:0047485	protein N-terminus binding	Molecular Function	IEA
GO:0047915	ganglioside galactosyltransferase activity	Molecular Function	IEA
GO:0016874	ligase activity	Molecular Function	IEA
GO:0050681	androgen receptor binding	Molecular Function	IEA
GO:0051082	unfolded protein binding	Molecular Function	IEA
GO:0042803	protein homodimerization activity	Molecular Function	ISS
GO:0008134	transcription factor binding	Molecular Function	ISS
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0008378	galactosyltransferase activity	Molecular Function	IEA
GO:0046873	metal ion transmembrane transporter activity	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0043565	sequence-specific DNA binding	Molecular Function	IEA
GO:0016439	tRNA-pseudouridine synthase activity	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0016757	transferase activity, transferring glycosyl groups	Molecular Function	IEA
GO:0016564	transcription repressor activity	Molecular Function	IEA
GO:0004714	transmembrane receptor protein tyrosine kinase activity	Molecular Function	IEA
GO:0003702	RNA polymerase II transcription factor activity	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0003707	steroid hormone receptor activity	Molecular Function	IEA
GO:0005201	extracellular matrix structural constituent	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IEA
GO:0005215	transporter activity	Molecular Function	IEA
GO:0005509	calcium ion binding	Molecular Function	IEA
GO:0005496	steroid binding	Molecular Function	IEA
GO:0005164	tumor necrosis factor receptor binding	Molecular Function	IEA
GO:0003700	transcription factor activity	Molecular Function	IEA
GO:0004812	aminoacyl-tRNA ligase activity	Molecular Function	IEA
GO:0004832	valine-tRNA ligase activity	Molecular Function	IEA
GO:0004872	receptor activity	Molecular Function	IEA
GO:0005085	guanyl-nucleotide exchange factor activity	Molecular Function	IEA
GO:0005125	cytokine activity	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0003676	nucleic acid binding	Molecular Function	IEA
GO:0005488	binding	Molecular Function	IEA
GO:0030154	cell differentiation	Biological Process	IEA
GO:0030521	androgen receptor signaling pathway	Biological Process	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0045892	negative regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	Biological Process	IEA
GO:0000902	cell morphogenesis	Biological Process	IEA
GO:0000281	cytokinesis after mitosis	Biological Process	IEA
GO:0051017	actin filament bundle formation	Biological Process	IEA
GO:0051056	regulation of small GTPase mediated signal transduction	Biological Process	IEA
GO:0030001	metal ion transport	Biological Process	IEA
GO:0019885	antigen processing and presentation of endogenous peptide antigen via MHC class I	Biological Process	IEA
GO:0019882	antigen processing and presentation	Biological Process	IEA
GO:0006350	transcription	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0006418	tRNA aminoacylation for protein translation	Biological Process	IEA
GO:0006438	valyl-tRNA aminoacylation	Biological Process	IEA
GO:0006486	protein amino acid glycosylation	Biological Process	IEA
GO:0006810	transport	Biological Process	IEA
GO:0006817	phosphate transport	Biological Process	IEA
GO:0006915	apoptosis	Biological Process	IEA
GO:0006955	immune response	Biological Process	IEA
GO:0007155	cell adhesion	Biological Process	IEA
GO:0007165	signal transduction	Biological Process	IEA
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	Biological Process	IEA
GO:0008152	metabolic process	Biological Process	IEA
GO:0006457	protein folding	Biological Process	IEA
GO:0006281	DNA repair	Biological Process	IEA