ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Mkks

Full Name:

McKusick-Kaufman syndrome protein

Alias:

MGC95109

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

3q36

Physical Location:

124975098-124993344 on NC_005102.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 8195 Symbol (Name): MKKS (McKusick-Kaufman syndrome)

Ortholog Status:

The human GeneID 8195 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Mkks
Fold Change:		-1.15
P Value:		0.004
Note:		Differential expression between ethanol and water groups in nucleus accumbens

Gene Information

Original ID1:		Mkks
Fold Change:		1.13
P Value:		0.007
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001008353.1	NP_001008354.1	NC_005102.2 range: 124975098..124993344, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005622	intracellular	Cellular Component	ISS
GO:0005575	cellular_component	Cellular Component	ND
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0051082	unfolded protein binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	ISS
GO:0003674	molecular_function	Molecular Function	ND
GO:0050910	detection of mechanical stimulus involved in sensory perception of sound	Biological Process	ISS
GO:0045494	photoreceptor cell maintenance	Biological Process	ISS
GO:0035176	social behavior	Biological Process	ISS
GO:0035058	sensory cilium biogenesis	Biological Process	ISS
GO:0009296	flagellum biogenesis	Biological Process	ISS
GO:0008150	biological_process	Biological Process	ND
GO:0007286	spermatid development	Biological Process	ISS
GO:0006457	protein folding	Biological Process	IEA
GO:0007608	sensory perception of smell	Biological Process	ISS