ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Pgd

Alias:

6-PGD|6PGD|6PGDH|A7|CG3724|EG:87B1.4|N1|Pdg|l(1)2Dc|l(1)2De|l(1)A7|l(1)G0385|l(1)N1|l(1)N3[90]|l(1)Pgd|l(1)Pgd-A|l35

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

2D4-2D4

Physical Location:

2039168-2042598 on NC_004354.3

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5226 Symbol (Name): PGD (phosphogluconate dehydrogenase)

Ortholog Status:

The human GeneID 5226 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Pgd
P Value:		4.27E-02
Note:		Slow up-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_057512.3	NP_476860.2	NC_004354.3 range: 2039168..2042598

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity	Molecular Function	IEA
GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity	Molecular Function	NAS
GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity	Molecular Function	TAS (1582561)
GO:0004672	protein kinase activity	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0050661	NADP binding	Molecular Function	IEA
GO:0006098	pentose-phosphate shunt	Biological Process	IEA
GO:0006098	pentose-phosphate shunt	Biological Process	NAS
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA