ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Alias:

CG3228|EG:30B8.2|N1|N8|l(1)2Eb|l(1)N4|l67

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

2F1-2F1

Physical Location:

2131955-2136070 on NC_004354.3, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 57647 Symbol (Name): DHX37 (DEAH (Asp-Glu-Ala-His) box polypeptide 37)

Ortholog Status:

The human GeneID 57647 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		kz
P Value:		6.11E-03
Note:		Slow up-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_057243.3	NP_476591.1	NC_004354.3 range: 2131955..2136070, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	ISS
GO:0003676	nucleic acid binding	Molecular Function	IEA
GO:0004252	serine-type endopeptidase activity	Molecular Function	IEA
GO:0004386	helicase activity	Molecular Function	ISS (10908586)
GO:0005524	ATP binding	Molecular Function	IEA
GO:0008026	ATP-dependent helicase activity	Molecular Function	ISS
GO:0008026	ATP-dependent helicase activity	Molecular Function	NAS
GO:0006508	proteolysis	Biological Process	IEA