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Gene Information
Gene ID:31239
Symbol:egh
Alias:CG9659|EG:BACR25B3.8|ZW-4|l(1)3Ae|l(1)zw4|zw4
Organism:Drosophila melanogaster (Fly)
Chromosome:X
Genetic Location:3A6-3A6
Physical Location:2482533-2492637 on NC_004354.3
Gene Type:protein-coding
Human Ortholog:This gene has no human ortholog.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:egh
P Value:4.52E-02
Note:Slow up-regulation
Dataset Information
Name:17054780
Method:Microarray
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_080313.2NP_525052.1NC_004354.3 range: 2482533..2492637
NM_166946.1NP_726818.1NC_004354.3 range: 2482533..2492637
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005887integral to plasma membraneCellular ComponentNAS
GO:0019187beta-1,4-mannosyltransferase activityMolecular FunctionIDA (12454022)
GO:0046662regulation of ovipositionBiological ProcessIMP (16979554)
GO:0045434negative regulation of female receptivity, post-matingBiological ProcessIMP (16979554)
GO:0045165cell fate commitmentBiological ProcessIMP (9533964)
GO:0042248maintenance of polarity of follicular epitheliumBiological ProcessIMP (9012507)
GO:0030720oocyte localization during germarium-derived egg chamber formationBiological ProcessIMP (9533964)
GO:0030707ovarian follicle cell developmentBiological ProcessTAS (10822261)
GO:0030707ovarian follicle cell developmentBiological ProcessIMP (9012507|9533964)
GO:0001744optic lobe placode formationBiological ProcessIMP (16182276)
GO:0016333morphogenesis of follicular epitheliumBiological ProcessIMP (9012507)
GO:0016325oocyte microtubule cytoskeleton organizationBiological ProcessIMP (9533964)
GO:0007411axon guidanceBiological ProcessIMP (16979554)
GO:0007299ovarian follicle cell adhesionBiological ProcessIMP (9012507)
GO:0007298border follicle cell migrationBiological ProcessIMP (9012507)
GO:0007293germarium-derived egg chamber formationBiological ProcessIMP (9012507)
GO:0007281germ cell developmentBiological ProcessIMP (9533964)
GO:0048477oogenesisBiological ProcessTAS (11131529)
Other Database Cross Links
NCBI Entrez Gene:31239
FLYBASE:FBgn0001404