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Gene Information
Gene ID:31251
Symbol:per
Alias:CG2647|Clk|EG:155E2.4|clk-6|dPER|unamed
Organism:Drosophila melanogaster (Fly)
Chromosome:X
Genetic Location:3B1-3B2
Physical Location:2579612-2586812 on NC_004354.3
Gene Type:protein-coding
Human Ortholog:This gene has no human ortholog.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:per
P Value:1.06E-04
Note:Slow up-regulation
Dataset Information
Name:17054780
Method:Microarray
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_080317.2NP_525056.2NC_004354.3 range: 2579612..2586812
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentIDA (12944510|15356209|16410523)
GO:0005737cytoplasmCellular ComponentTAS (12626480)
GO:0005737cytoplasmCellular ComponentNAS (12015613)
GO:0005634nucleusCellular ComponentTAS (12486701|12626480)
GO:0005634nucleusCellular ComponentIDA (12944510|15356209|15930393|16410523)
GO:0005634nucleusCellular ComponentNAS (12015613)
GO:0046982protein heterodimerization activityMolecular FunctionNAS (11178250)
GO:0004871signal transducer activityMolecular FunctionIEA
GO:0003714transcription corepressor activityMolecular FunctionTAS (12486701)
GO:0003712transcription cofactor activityMolecular FunctionNAS (11715043)
GO:0046982protein heterodimerization activityMolecular FunctionTAS (15312644)
GO:0009266response to temperature stimulusBiological ProcessTAS (12626480)
GO:0009416response to light stimulusBiological ProcessTAS (12626480)
GO:0009649entrainment of circadian clockBiological ProcessIMP (16085487)
GO:0042745circadian sleep/wake cycleBiological ProcessTAS (12111533)
GO:0043153entrainment of circadian clock by photoperiodBiological ProcessIMP (16361445)
GO:0045187regulation of circadian sleep/wake cycle, sleepBiological ProcessIMP (12015603)
GO:0045433male courtship behavior, veined wing generated song productionBiological ProcessNAS (11092827)
GO:0045433male courtship behavior, veined wing generated song productionBiological ProcessTAS (12486700)
GO:0045475locomotor rhythmBiological ProcessNAS (11715043|12015613)
GO:0045475locomotor rhythmBiological ProcessTAS (12626480)
GO:0000122negative regulation of transcription from RNA polymerase II promoterBiological ProcessNAS (12015613)
GO:0008062eclosion rhythmBiological ProcessTAS (12015613|12111533|12486701|12626480)
GO:0008062eclosion rhythmBiological ProcessNAS (11715043)
GO:0000122negative regulation of transcription from RNA polymerase II promoterBiological ProcessTAS (11178250|12486701)
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIEA
GO:0007165signal transductionBiological ProcessIEA
GO:0007616long-term memoryBiological ProcessIMP (15522971)
GO:0007617mating behaviorBiological ProcessIMP (11470898)
GO:0007619courtship behaviorBiological ProcessNAS (11715043)
GO:0007620copulationBiological ProcessIMP (15324667)
GO:0007622rhythmic behaviorBiological ProcessTAS (12486701)
GO:0007623circadian rhythmBiological ProcessIMP (12417656|12944510|16319317)
GO:0007623circadian rhythmBiological ProcessNAS (11092827|11715043)
GO:0007623circadian rhythmBiological ProcessTAS (11178250|12154068|15312644)
GO:0007624ultradian rhythmBiological ProcessNAS
GO:0048148behavioral response to cocaineBiological ProcessNAS (11715043)
Other Database Cross Links
NCBI Entrez Gene:31251
FLYBASE:FBgn0003068