ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

ctp

Alias:

CG6998|Cdlc1|Ddlc-1|Ddlc1|Dlc|LC8|anon-WO03040301.128|l(1)G0153|l(1)G0204|l(1)G0207|l(1)G0244|l(1)G0248|l(1)G0338|l(1)G0371|l(1)G0387|l(1)G0432|l(1)G0445

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

4C13-4C14

Physical Location:

4581833-4593917 on NC_004354.3

Gene Type:

protein-coding

Human Ortholog:

GeneID: 140735 Symbol (Name): DYNLL2 (dynein, light chain, LC8-type 2)

Ortholog Status:

The human GeneID 140735 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		ctp
P Value:		4.52E-02
Note:		Acute up-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_080336.3	NP_525075.1	NC_004354.3 range: 4581833..4593917
NM_167014.1	NP_726942.1	NC_004354.3 range: 4581833..4593917
NM_167015.2	NP_726943.1	NC_004354.3 range: 4581833..4593917
NM_167016.1	NP_726944.1	NC_004354.3 range: 4581833..4593917

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005868	cytoplasmic dynein complex	Cellular Component	NAS
GO:0030286	dynein complex	Cellular Component	ISS (10908588)
GO:0005856	cytoskeleton	Cellular Component	NAS
GO:0005868	cytoplasmic dynein complex	Cellular Component	ISS
GO:0042623	ATPase activity, coupled	Molecular Function	ISS (10908588)
GO:0003777	microtubule motor activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (17362353)
GO:0003777	microtubule motor activity	Molecular Function	NAS
GO:0008407	bristle morphogenesis	Biological Process	IMP (15020714)
GO:0007476	imaginal disc-derived wing morphogenesis	Biological Process	IMP (15020714)
GO:0007291	sperm individualization	Biological Process	IMP (15829565)
GO:0007290	spermatid nuclear elongation	Biological Process	IMP (15829565)
GO:0007283	spermatogenesis	Biological Process	IMP (15020714)
GO:0007018	microtubule-based movement	Biological Process	ISS (10908588)
GO:0007017	microtubule-based process	Biological Process	IEA
GO:0051017	actin filament bundle formation	Biological Process	IMP (15829565)