Logo
Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:314442
Symbol:Wars
Full Name:tryptophanyl-tRNA synthetase
Organism:Rattus norvegicus (Rat)
Chromosome:6
Genetic Location:6q32
Physical Location:133200865-133232047 on NC_005105.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 7453    Symbol (Name): WARS (tryptophanyl-tRNA synthetase)
Ortholog Status:The human GeneID 7453 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Wars
Fold Change:-1.13
P Value:0.006
Note:Differential expression between ethanol and water groups in nucleus accumbens
Dataset Information
Name:18405950
Method:Microarray
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001013170.2NP_001013188.2NC_005105.2 range: 133200865..133232047, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentIEA
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0004830tryptophan-tRNA ligase activityMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionIEA
GO:0016874ligase activityMolecular FunctionIEA
GO:0006436tryptophanyl-tRNA aminoacylationBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:314442
RGD:1308278
Ensembl:ENSRNOG00000004359
dbSNP:Wars