ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CG3585

Alias:

DmX|X|anon-X

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

5E1-5E3

Physical Location:

6135433-6147286 on NC_004354.3, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 23312 Symbol (Name): DMXL2 (Dmx-like 2)

Ortholog Status:

The human GeneID 23312 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		CG3585
P Value:		4.31E-02
Note:		Slow up-regulation, have human orthologs

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_132074.1	NP_572302.1	NC_004354.3 range: 6135433..6147286, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005874	microtubule	Cellular Component	IEA
GO:0004379	glycylpeptide N-tetradecanoyltransferase activity	Molecular Function	IEA
GO:0005525	GTP binding	Molecular Function	IEA
GO:0006499	N-terminal protein myristoylation	Biological Process	IEA
GO:0007017	microtubule-based process	Biological Process	IEA
GO:0007424	open tracheal system development	Biological Process	IMP