| Gene Information |
| Gene ID: | | 315608 |
| Symbol: | | Ube4a |
| Full Name: | | ubiquitination factor E4A, UFD2 homolog (S. cerevisiae) |
| Alias: | | Ab2-232 |
| Organism: | | Rattus norvegicus (Rat) |
| Chromosome: | | 8 |
| Genetic Location: | | 8q22 |
| Physical Location: | | 47879265-47921147 on NC_005107.2, complement |
| Gene Type: | | protein-coding |
| Human Ortholog: | | GeneID: 9354 Symbol (Name): UBE4A (ubiquitination factor E4A (UFD2 homolog, yeast)) |
| Ortholog Status: | | The human GeneID 9354 is not in current human dataset. |
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| Gene in Ethanol Study Datasets |
| Gene Information | | Original ID1: | | Ube4a | | Fold Change: | | -1.12 | | P Value: | | 0.01 | | Note: | | Differential expression between ethanol and water groups in nucleus accumbens |
| | Gene Information | | Original ID1: | | Ube4a | | Fold Change: | | -1.13 | | P Value: | | 0.006 | | Note: | | Differential expression between ethanol and saccharin groups in nucleus accumbens |
| | Dataset Information | | Name: | | 18405950 | | Method: | | Microarray | | Tissue: | | Nucleus accumbens and amygdala | | Phenotype: | | Ethanol self-administration, alcohol-preferring | | Publication: | | Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed | | Summary: | | The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group. |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0000151 | ubiquitin ligase complex | Cellular Component | IEA | |
| GO:0004842 | ubiquitin-protein ligase activity | Molecular Function | IEA | |
| GO:0005515 | protein binding | Molecular Function | ISS | |
| GO:0006512 | ubiquitin cycle | Biological Process | ISS | |
| GO:0016567 | protein ubiquitination | Biological Process | IEA | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 315608 |
| RGD: | | 1303173 |
| Ensembl: | | ENSRNOG00000026833 |
| dbSNP: | | Ube4a |
