Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:315608
Full Name:ubiquitination factor E4A, UFD2 homolog (S. cerevisiae)
Organism:Rattus norvegicus (Rat)
Genetic Location:8q22
Physical Location:47879265-47921147 on NC_005107.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 9354    Symbol (Name): UBE4A (ubiquitination factor E4A (UFD2 homolog, yeast))
Ortholog Status:The human GeneID 9354 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Ube4a
Fold Change:-1.12
P Value:0.01
Note:Differential expression between ethanol and water groups in nucleus accumbens
Gene Information
Original ID1:Ube4a
Fold Change:-1.13
P Value:0.006
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_207610.1NP_997493.1NC_005107.2 range: 47879265..47921147, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0000151ubiquitin ligase complexCellular ComponentIEA
GO:0004842ubiquitin-protein ligase activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionISS
GO:0006512ubiquitin cycleBiological ProcessISS
GO:0016567protein ubiquitinationBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:315608