ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Spat

Alias:

CG3926|Dm-Spat|spa

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

6B1-6B1

Physical Location:

6422980-6424758 on NC_004354.3

Gene Type:

protein-coding

Human Ortholog:

GeneID: 189 Symbol (Name): AGXT (alanine-glyoxylate aminotransferase)

Ortholog Status:

The human GeneID 189 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Spat
P Value:		3.04E-02
Note:		Slow down-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_078507.2	NP_511062.1	NC_004354.3 range: 6422980..6424758

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005759	mitochondrial matrix	Cellular Component	ISS
GO:0005777	peroxisome	Cellular Component	ISS
GO:0005811	lipid particle	Cellular Component	IDA
GO:0004760	serine-pyruvate transaminase activity	Molecular Function	ISS
GO:0004760	serine-pyruvate transaminase activity	Molecular Function	NAS
GO:0008453	alanine-glyoxylate transaminase activity	Molecular Function	IDA (12220660)
GO:0008453	alanine-glyoxylate transaminase activity	Molecular Function	ISS
GO:0030170	pyridoxal phosphate binding	Molecular Function	IEA
GO:0009436	glyoxylate catabolic process	Biological Process	IDA (12220660)