ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

HMOX1

Full Name:

heme oxygenase (decycling) 1

Alias:

HO-1|bK286B10

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

22q12|22q13.1

Physical Location:

34107086-34120193 on NC_000022.9

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 15368 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

Z82244

Dataset Information

Name:		12065639
Method:		Microarray
Tissue:		Frontal and motor cortices
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Mayfield et al. J Neurochem. (2002) Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics. PubMed
Summary:		We used cDNA microarrays to analyze expression of approximately 10 000 genes in the frontal and motor cortices of three groups of chronic alcoholic and matched control cases. Fluorescent intensity ratios of 1.4-fold or greater in either direction (representing the 99% confidence interval) were used to indicate differentially expressed genes.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_002133.1	NP_002124.1	NC_000022.9 range: 34107086..34120193

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005792	microsome	Cellular Component	IEA
GO:0005624	membrane fraction	Cellular Component	TAS (3345742)
GO:0005783	endoplasmic reticulum	Cellular Component	TAS (3345742)
GO:0016491	oxidoreductase activity	Molecular Function	IEA
GO:0004392	heme oxygenase (decyclizing) activity	Molecular Function	TAS (9884342)
GO:0005506	iron ion binding	Molecular Function	IEA
GO:0004871	signal transducer activity	Molecular Function	IMP (12761501)
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0006788	heme oxidation	Biological Process	IEA
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	Biological Process	IMP (12761501)