ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

rdgA

Alias:

CG10966|CG12660|CG34344|DGK|DGK2|Dmel_CG10966|Dmel_CG12660|dDGK2|x35

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

8B7-8B7

Physical Location:

8806400-8919836 on NC_004354.3

Gene Type:

protein-coding

Human Ortholog:

This gene has no human ortholog.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		rdgA
P Value:		4.02E-02
Note:		Slow up-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	NAS
GO:0019992	diacylglycerol binding	Molecular Function	NAS
GO:0019992	diacylglycerol binding	Molecular Function	ISS
GO:0004143	diacylglycerol kinase activity	Molecular Function	ISS (8248222)
GO:0004143	diacylglycerol kinase activity	Molecular Function	NAS (10908587)
GO:0004143	diacylglycerol kinase activity	Molecular Function	TAS (7816126\|11707492)
GO:0007015	actin filament organization	Biological Process	IMP (14527345)
GO:0046489	phosphoinositide biosynthetic process	Biological Process	TAS (10611962)
GO:0045494	photoreceptor cell maintenance	Biological Process	TAS (11707492)
GO:0045494	photoreceptor cell maintenance	Biological Process	NAS
GO:0016310	phosphorylation	Biological Process	NAS (10908587)
GO:0016059	deactivation of rhodopsin mediated signaling	Biological Process	IGI (10798401)
GO:0016056	rhodopsin mediated signaling pathway	Biological Process	IMP (10798401)
GO:0006654	phosphatidic acid biosynthetic process	Biological Process	TAS (11707492)
GO:0007602	phototransduction	Biological Process	TAS (10611962)
GO:0007602	phototransduction	Biological Process	IMP (16513351)
GO:0007601	visual perception	Biological Process	NAS
GO:0007205	activation of protein kinase C activity	Biological Process	IEA
GO:0046834	lipid phosphorylation	Biological Process	TAS (11707492)