ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Ost48

Alias:

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

8C14-8C14

Physical Location:

9050954-9052543 on NC_004354.3, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1650 Symbol (Name): DDOST (dolichyl-diphosphooligosaccharide-protein glycosyltransferase)

Ortholog Status:

The human GeneID 1650 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Ost48
P Value:		4.43E-02
Note:		Acute down-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_078541.3	NP_511096.2	NC_004354.3 range: 9050954..9052543, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005789	endoplasmic reticulum membrane	Cellular Component	IEA
GO:0005811	lipid particle	Cellular Component	IDA (16979555)
GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	Molecular Function	ISS
GO:0006487	protein amino acid N-linked glycosylation	Biological Process	NAS
GO:0018279	protein amino acid N-linked glycosylation via asparagine	Biological Process	IEA