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Gene Information
Gene ID:31873
Symbol:CG17754
Organism:Drosophila melanogaster (Fly)
Chromosome:X
Genetic Location:8D3-8D3
Physical Location:9144459-9149852 on NC_004354.3
Gene Type:protein-coding
Human Ortholog:GeneID: 51088    Symbol (Name): KLHL5 (kelch-like 5 (Drosophila))
Ortholog Status:The human GeneID 51088 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:CG17754
P Value:3.19E-02
Note:Transient down-regulation
Dataset Information
Name:17054780
Method:Microarray
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_132321.3NP_572549.2NC_004354.3 range: 9144459..9149852
NM_167187.1NP_727331.1NC_004354.3 range: 9144459..9149852
NM_176721.1NP_788894.1NC_004354.3 range: 9144459..9149852
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005515protein bindingMolecular FunctionIEA
GO:0006911phagocytosis, engulfmentBiological ProcessIMP (16336044)
Other Database Cross Links
NCBI Entrez Gene:31873
FLYBASE:FBgn0030114