ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CG11727

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

10B11-10B14

Physical Location:

11326944-11348334 on NC_004354.3, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 115704 Symbol (Name): EVI5L (ecotropic viral integration site 5-like)

Ortholog Status:

The human GeneID 115704 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		CG11727
P Value:		3.02E-02
Note:		Acute up-regulation, have mouse orthologs

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005622	intracellular	Cellular Component	IEA
GO:0005097	Rab GTPase activator activity	Molecular Function	IEA
GO:0032313	regulation of Rab GTPase activity	Biological Process	IEA