ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Pkcdelta

Alias:

CG10524|PKCd

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

11A10-11A11

Physical Location:

12326258-12347682 on NC_004354.3

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5580 Symbol (Name): PRKCD (protein kinase C, delta)

Ortholog Status:

The human GeneID 5580 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Pkcdelta
P Value:		3.08E-02
Note:		Slow up-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_078616.3	NP_511171.3	NC_004354.3 range: 12326258..12347682

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0004674	protein serine/threonine kinase activity	Molecular Function	NAS (10908587)
GO:0004697	protein kinase C activity	Molecular Function	ISS
GO:0005524	ATP binding	Molecular Function	IEA
GO:0019992	diacylglycerol binding	Molecular Function	ISS
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	NAS (10908587)
GO:0007242	intracellular signaling cascade	Biological Process	IEA