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Gene Information
Gene ID:32225
Symbol:Smr
Alias:CG4013|E52|SMRTER|anon-WO0153538.73|l(1)G0361
Organism:Drosophila melanogaster (Fly)
Chromosome:X
Genetic Location:11B10-11B14
Physical Location:12580030-12636475 on NC_004354.3, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 9611    Symbol (Name): NCOR1 (nuclear receptor co-repressor 1)
Ortholog Status:The human GeneID 9611 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Smr
P Value:1.71E-02
Note:Slow up-regulation
Dataset Information
Name:17054780
Method:Microarray
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_080536.2NP_536797.2NC_004354.3 range: 12580030..12636475, complement
NM_167334.1NP_727634.1NC_004354.3 range: 12580030..12636475, complement
NM_167335.1NP_727635.1NC_004354.3 range: 12580030..12636475, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005700polytene chromosomeCellular ComponentNAS (10920384)
GO:0003677DNA bindingMolecular FunctionIEA
GO:0016491oxidoreductase activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionTAS (10920384)
GO:0005515protein bindingMolecular FunctionIPI (16763555)
GO:0003714transcription corepressor activityMolecular FunctionTAS (10920384)
GO:0003714transcription corepressor activityMolecular FunctionNAS
GO:0003714transcription corepressor activityMolecular FunctionISS
GO:0006911phagocytosis, engulfmentBiological ProcessIMP (16336044)
GO:0008152metabolic processBiological ProcessIEA
GO:0045892negative regulation of transcription, DNA-dependentBiological ProcessTAS (10920384)
Other Database Cross Links
NCBI Entrez Gene:32225
FLYBASE:FBgn0024308