ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Smr

Alias:

CG4013|E52|SMRTER|anon-WO0153538.73|l(1)G0361

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

11B10-11B14

Physical Location:

12580030-12636475 on NC_004354.3, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 9611 Symbol (Name): NCOR1 (nuclear receptor co-repressor 1)

Ortholog Status:

The human GeneID 9611 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005700	polytene chromosome	Cellular Component	NAS (10920384)
GO:0003677	DNA binding	Molecular Function	IEA
GO:0016491	oxidoreductase activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	TAS (10920384)
GO:0005515	protein binding	Molecular Function	IPI (16763555)
GO:0003714	transcription corepressor activity	Molecular Function	TAS (10920384)
GO:0003714	transcription corepressor activity	Molecular Function	NAS
GO:0003714	transcription corepressor activity	Molecular Function	ISS
GO:0006911	phagocytosis, engulfment	Biological Process	IMP (16336044)
GO:0008152	metabolic process	Biological Process	IEA
GO:0045892	negative regulation of transcription, DNA-dependent	Biological Process	TAS (10920384)