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Gene Information
Gene ID:32275
Symbol:mew
Alias:CG1771|CT5254|PS1|PS1alpha|aPS1|alpha-PS1|alphaPS1|alpha[[PS1]]|l(1)G0429|l(1)G0443
Organism:Drosophila melanogaster (Fly)
Chromosome:X
Genetic Location:11E3-11E8
Physical Location:13108441-13152522 on NC_004354.3, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 3679    Symbol (Name): ITGA7 (integrin, alpha 7)
Ortholog Status:The human GeneID 3679 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:mew
P Value:4.70E-02
Note:Slow down-regulation, have human and mouse orthologs.
Dataset Information
Name:17054780
Method:Microarray
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_078590.2NP_511145.2NC_004354.3 range: 13108441..13152522, complement
NM_167354.1NP_727679.1NC_004354.3 range: 13108441..13152522, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0008305integrin complexCellular ComponentNAS (14519396)
GO:0008305integrin complexCellular ComponentISS (10908592|10936444)
GO:0004872receptor activityMolecular FunctionIMP (7750648)
GO:0050839cell adhesion molecule bindingMolecular FunctionIMP (7750648)
GO:0050839cell adhesion molecule bindingMolecular FunctionISS (10908592)
GO:0004872receptor activityMolecular FunctionISS (10908592)
GO:0007411axon guidanceBiological ProcessIMP (12040052)
GO:0007157heterophilic cell adhesionBiological ProcessTAS (10908592)
GO:0007155cell adhesionBiological ProcessIMP (7750648)
GO:0016337cell-cell adhesionBiological ProcessTAS (10936444)
GO:0016477cell migrationBiological ProcessTAS (10936444)
GO:0030154cell differentiationBiological ProcessTAS (10936444)
GO:0035160maintenance of epithelial integrity, open tracheal systemBiological ProcessIGI (16720877)
GO:0048567ectodermal gut morphogenesisBiological ProcessTAS (10936444)
GO:0007494midgut developmentBiological ProcessTAS (10936444)
GO:0007476imaginal disc-derived wing morphogenesisBiological ProcessTAS (10936444)
GO:0007424open tracheal system developmentBiological ProcessNAS (12885551)
GO:0007426tracheal outgrowth, open tracheal systemBiological ProcessTAS (14570584)
GO:0007427epithelial cell migration, open tracheal systemBiological ProcessTAS (11835274|12791296)
GO:0007431salivary gland developmentBiological ProcessTAS (12742168)
GO:0007432salivary gland boundary specificationBiological ProcessIMP (15950216)
GO:0007475apposition of dorsal and ventral imaginal disc-derived wing surfacesBiological ProcessNAS (14519396)
GO:0007160cell-matrix adhesionBiological ProcessISS (10908592)
GO:0007476imaginal disc-derived wing morphogenesisBiological ProcessIMP (8898242)
GO:0007476imaginal disc-derived wing morphogenesisBiological ProcessIEP (8898242)
Other Database Cross Links
NCBI Entrez Gene:32275
FLYBASE:FBgn0004456