ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

IP3K2

Alias:

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

11E11-11E11

Physical Location:

13212684-13223349 on NC_004354.3

Gene Type:

protein-coding

Human Ortholog:

This gene has no human ortholog.

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005516	calmodulin binding	Molecular Function	IDA
GO:0008440	inositol trisphosphate 3-kinase activity	Molecular Function	IDA (15322119)
GO:0008440	inositol trisphosphate 3-kinase activity	Molecular Function	ISS
GO:0048306	calcium-dependent protein binding	Molecular Function	IDA
GO:0046853	inositol and derivative phosphorylation	Biological Process	IDA (15322119)