ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CG33174

Alias:

CG11102|EP(X)1101

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

12C4-12C5

Physical Location:

13677781-13705533 on NC_004354.3

Gene Type:

protein-coding

Human Ortholog:

GeneID: 747 Symbol (Name): DAGLA (diacylglycerol lipase, alpha)

Ortholog Status:

The human GeneID 747 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		CG33174
P Value:		3.74E-02
Note:		Slow up-regulation, have mouse orthologs

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0004806	triacylglycerol lipase activity	Molecular Function	IEA
GO:0006629	lipid metabolic process	Biological Process	IEA