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Gene Information
Gene ID:32382
Organism:Drosophila melanogaster (Fly)
Genetic Location:12E6-12E6
Physical Location:14159600-14160370 on NC_004354.3, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 55848    Symbol (Name): C9orf46 (chromosome 9 open reading frame 46)
Ortholog Status:The human GeneID 55848 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:CG13404
P Value:5.47E-03
Note:Slow up-regulation
Dataset Information
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_132726.1NP_572954.1NC_004354.3 range: 14159600..14160370, complement
Other Database Cross Links
NCBI Entrez Gene:32382