ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CG9065

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

13A9-13A9

Physical Location:

14978053-14978687 on NC_004354.3, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 10063 Symbol (Name): COX17 (COX17 cytochrome c oxidase assembly homolog (S. cerevisiae))

Ortholog Status:

The human GeneID 10063 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_132770.1	NP_572998.1	NC_004354.3 range: 14978053..14978687, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005758	mitochondrial intermembrane space	Cellular Component	ISS
GO:0005507	copper ion binding	Molecular Function	IEA
GO:0016531	copper chaperone activity	Molecular Function	ISS
GO:0006825	copper ion transport	Biological Process	IEA
GO:0008535	respiratory chain complex IV assembly	Biological Process	ISS