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Gene Information
Gene ID:32439
Organism:Drosophila melanogaster (Fly)
Genetic Location:13A9-13A9
Physical Location:14978053-14978687 on NC_004354.3, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 10063    Symbol (Name): COX17 (COX17 cytochrome c oxidase assembly homolog (S. cerevisiae))
Ortholog Status:The human GeneID 10063 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:CG9065
P Value:2.62E-02
Note:Acute up-regulation
Dataset Information
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_132770.1NP_572998.1NC_004354.3 range: 14978053..14978687, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005758mitochondrial intermembrane spaceCellular ComponentISS
GO:0005507copper ion bindingMolecular FunctionIEA
GO:0016531copper chaperone activityMolecular FunctionISS
GO:0006825copper ion transportBiological ProcessIEA
GO:0008535respiratory chain complex IV assemblyBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:32439