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Gene Information
Gene ID:32470
Organism:Drosophila melanogaster (Fly)
Genetic Location:13C3-13C3
Physical Location:15340210-15343921 on NC_004354.3, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 9522    Symbol (Name): SCAMP1 (secretory carrier membrane protein 1)
Ortholog Status:The human GeneID 9522 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Scamp
P Value:3.76E-02
Note:Acute up-regulation, have human and mouse orthologs.
Dataset Information
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_132795.2NP_573023.2NC_004354.3 range: 15340210..15343921, complement
NM_167442.1NP_727850.1NC_004354.3 range: 15340210..15343921, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0008021synaptic vesicleCellular ComponentNAS (10798391)
GO:0016021integral to membraneCellular ComponentIEA
GO:0031177phosphopantetheine bindingMolecular FunctionIEA
GO:0015031protein transportBiological ProcessIEA
GO:0016079synaptic vesicle exocytosisBiological ProcessISS (10908590)
Other Database Cross Links
NCBI Entrez Gene:32470