ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Ac13E

Alias:

AC 13E|Ac35C|CG9210|DAC9

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

13C7-13C8

Physical Location:

15404908-15416195 on NC_004354.3, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 115 Symbol (Name): ADCY9 (adenylate cyclase 9)

Ortholog Status:

The human GeneID 115 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Ac13E
P Value:		3.18E-02
Note:		Slow down-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0004016	adenylate cyclase activity	Molecular Function	ISS
GO:0004016	adenylate cyclase activity	Molecular Function	NAS (10908587)
GO:0007242	intracellular signaling cascade	Biological Process	IEA
GO:0009190	cyclic nucleotide biosynthetic process	Biological Process	IEA