ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Gbeta13F

Alias:

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

13F16-13F16

Physical Location:

15754158-15756918 on NC_004354.3

Gene Type:

protein-coding

Human Ortholog:

GeneID: 2782 Symbol (Name): GNB1 (guanine nucleotide binding protein (G protein), beta polypeptide 1)

Ortholog Status:

The human GeneID 2782 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Gbeta13F
P Value:		3.55E-02
Note:		Acute up-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005834	heterotrimeric G-protein complex	Cellular Component	ISS
GO:0005834	heterotrimeric G-protein complex	Cellular Component	NAS
GO:0003924	GTPase activity	Molecular Function	ISS
GO:0003924	GTPase activity	Molecular Function	NAS
GO:0007015	actin filament organization	Biological Process	IMP (14527345)
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	ISS
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	NAS
GO:0045176	apical protein localization	Biological Process	TAS (15324689)
GO:0055059	asymmetric neuroblast division	Biological Process	IMP (12925708)