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Gene Information
Gene ID:32588
Organism:Drosophila melanogaster (Fly)
Genetic Location:14B9-14B9
Physical Location:16187872-16191750 on NC_004354.3, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 23071    Symbol (Name): TXNDC4 (thioredoxin domain containing 4 (endoplasmic reticulum))
Ortholog Status:The human GeneID 23071 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:CG9911
P Value:4.71E-02
Note:Acute down-regulation, have human and mouse orthologs.
Dataset Information
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_132883.2NP_573111.1NC_004354.3 range: 16187872..16191750, complement
NM_167494.1NP_727947.1NC_004354.3 range: 16187872..16191750, complement
NM_167495.1NP_727948.1NC_004354.3 range: 16187872..16191750, complement
NM_167496.1NP_727949.1NC_004354.3 range: 16187872..16191750, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005783endoplasmic reticulumCellular ComponentIEA
GO:0003756protein disulfide isomerase activityMolecular FunctionISS
GO:0045454cell redox homeostasisBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:32588