ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Arpc3B

Alias:

BcDNA:SD24339|CG8936|P21-ARC

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

15E3-15E3

Physical Location:

16998605-16999884 on NC_004354.3, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 10094 Symbol (Name): ARPC3 (actin related protein 2/3 complex, subunit 3, 21kDa)

Ortholog Status:

The human GeneID 10094 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005856	cytoskeleton	Cellular Component	IEA
GO:0005885	Arp2/3 protein complex	Cellular Component	NAS
GO:0045172	germline ring canal	Cellular Component	IDA (11854308)
GO:0003779	actin binding	Molecular Function	ISS (10908588)
GO:0005200	structural constituent of cytoskeleton	Molecular Function	NAS
GO:0007015	actin filament organization	Biological Process	NAS
GO:0030833	regulation of actin filament polymerization	Biological Process	IEA