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Gene Information
Gene ID:32696
Organism:Drosophila melanogaster (Fly)
Genetic Location:15E3-15E3
Physical Location:16998605-16999884 on NC_004354.3, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 10094    Symbol (Name): ARPC3 (actin related protein 2/3 complex, subunit 3, 21kDa)
Ortholog Status:The human GeneID 10094 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Arpc3B
P Value:1.21E-02
Note:Acute up-regulation
Dataset Information
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001103539.1NP_001097009.1NC_004354.3 range: 16998605..16999884, complement
NM_132965.1NP_573193.1NC_004354.3 range: 16998605..16999884, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005856cytoskeletonCellular ComponentIEA
GO:0005885Arp2/3 protein complexCellular ComponentNAS
GO:0045172germline ring canalCellular ComponentIDA (11854308)
GO:0003779actin bindingMolecular FunctionISS (10908588)
GO:0005200structural constituent of cytoskeletonMolecular FunctionNAS
GO:0007015actin filament organizationBiological ProcessNAS
GO:0030833regulation of actin filament polymerizationBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:32696