ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Cyp18a1

Alias:

181H6T|18a1|CG6816|CT20826|CYP18|CYP18A1-Dm|Cyt-P450-17C|CytP450|ESTS:181H6T|Eig17-1|P-450|P450

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

17D1-17D1

Physical Location:

18582569-18586777 on NC_004354.3, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 113612 Symbol (Name): CYP2U1 (cytochrome P450, family 2, subfamily U, polypeptide 1)

Ortholog Status:

The human GeneID 113612 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Cyp18a1
P Value:		4.52E-02
Note:		Transient up-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005792	microsome	Cellular Component	NAS
GO:0016020	membrane	Cellular Component	NAS
GO:0004497	monooxygenase activity	Molecular Function	IEA
GO:0005506	iron ion binding	Molecular Function	IEA
GO:0009055	electron carrier activity	Molecular Function	ISS
GO:0009055	electron carrier activity	Molecular Function	NAS
GO:0020037	heme binding	Molecular Function	IEA
GO:0006694	steroid biosynthetic process	Biological Process	NAS