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Gene Information
Gene ID:32876
Symbol:Pvf1
Alias:CG7103|DmVEGF-1|EP1624|PVF|PVFs|VEGF|VEGF2-B|Vegf17E|Vegf17e-a|Vegf17e-b|l(1)G0146|unnamed|vegf1
Organism:Drosophila melanogaster (Fly)
Chromosome:X
Genetic Location:17E1-17E1
Physical Location:18726736-18736933 on NC_004354.3
Gene Type:protein-coding
Human Ortholog:GeneID: 7424    Symbol (Name): VEGFC (vascular endothelial growth factor C)
Ortholog Status:The human GeneID 7424 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Pvf1
P Value:4.65E-02
Note:Slow up-regulation
Dataset Information
Name:17054780
Method:Microarray
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_078683.2NP_523407.1NC_004354.3 range: 18726736..18736933
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016020membraneCellular ComponentIEA
GO:0005576extracellular regionCellular ComponentISS (11595182)
GO:0005737cytoplasmCellular ComponentIDA (11595182)
GO:0008201heparin bindingMolecular FunctionIDA (15056618)
GO:0008083growth factor activityMolecular FunctionIEA
GO:0005102receptor bindingMolecular FunctionIPI (11595182)
GO:0005172vascular endothelial growth factor receptor bindingMolecular FunctionNAS
GO:0005172vascular endothelial growth factor receptor bindingMolecular FunctionISS (11955438)
GO:0005102receptor bindingMolecular FunctionISS (11595182)
GO:0035099hemocyte migrationBiological ProcessIGI (11955438)
GO:0035099hemocyte migrationBiological ProcessIEP (11955438)
GO:0035099hemocyte migrationBiological ProcessTAS (12885551)
GO:0030031cell projection biogenesisBiological ProcessIMP (12198500)
GO:0007298border follicle cell migrationBiological ProcessTAS (12885551)
GO:0007298border follicle cell migrationBiological ProcessIMP (11595182|12810594|16712835)
GO:0007298border follicle cell migrationBiological ProcessIGI (12810594)
GO:0048010vascular endothelial growth factor receptor signaling pathwayBiological ProcessISS (11955438)
Other Database Cross Links
NCBI Entrez Gene:32876
FLYBASE:FBgn0030964