ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Pvf1

Alias:

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

17E1-17E1

Physical Location:

18726736-18736933 on NC_004354.3

Gene Type:

protein-coding

Human Ortholog:

GeneID: 7424 Symbol (Name): VEGFC (vascular endothelial growth factor C)

Ortholog Status:

The human GeneID 7424 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_078683.2	NP_523407.1	NC_004354.3 range: 18726736..18736933

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0005576	extracellular region	Cellular Component	ISS (11595182)
GO:0005737	cytoplasm	Cellular Component	IDA (11595182)
GO:0008201	heparin binding	Molecular Function	IDA (15056618)
GO:0008083	growth factor activity	Molecular Function	IEA
GO:0005102	receptor binding	Molecular Function	IPI (11595182)
GO:0005172	vascular endothelial growth factor receptor binding	Molecular Function	NAS
GO:0005172	vascular endothelial growth factor receptor binding	Molecular Function	ISS (11955438)
GO:0005102	receptor binding	Molecular Function	ISS (11595182)
GO:0035099	hemocyte migration	Biological Process	IGI (11955438)
GO:0035099	hemocyte migration	Biological Process	IEP (11955438)
GO:0035099	hemocyte migration	Biological Process	TAS (12885551)
GO:0030031	cell projection biogenesis	Biological Process	IMP (12198500)
GO:0007298	border follicle cell migration	Biological Process	TAS (12885551)
GO:0007298	border follicle cell migration	Biological Process	IMP (11595182\|12810594\|16712835)
GO:0007298	border follicle cell migration	Biological Process	IGI (12810594)
GO:0048010	vascular endothelial growth factor receptor signaling pathway	Biological Process	ISS (11955438)