ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CoRest

Alias:

BcDNA:GH01486|BcDNA:LD11215|CG32535|CG33525|CG3878|dCoREST|i169

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

18C8-18C8

Physical Location:

19415961-19424936 on NC_004354.3

Gene Type:

protein-coding

Human Ortholog:

GeneID: 283248 Symbol (Name): RCOR2 (REST corepressor 2)

Ortholog Status:

The human GeneID 283248 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IDA (15306652)
GO:0005634	nucleus	Cellular Component	ISS
GO:0003677	DNA binding	Molecular Function	IEA
GO:0003682	chromatin binding	Molecular Function	IDA (15306652)
GO:0003714	transcription corepressor activity	Molecular Function	IDA (15306652)
GO:0005515	protein binding	Molecular Function	IPI (15306652\|16763555)
GO:0016564	transcription repressor activity	Molecular Function	ISS
GO:0045892	negative regulation of transcription, DNA-dependent	Biological Process	ISS