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Gene Information
Gene ID:32941
Organism:Drosophila melanogaster (Fly)
Genetic Location:18C8-18C8
Physical Location:19415961-19424936 on NC_004354.3
Gene Type:protein-coding
Human Ortholog:GeneID: 283248    Symbol (Name): RCOR2 (REST corepressor 2)
Ortholog Status:The human GeneID 283248 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:CG33525
P Value:6.86E-05
Note:Slow up-regulation
Dataset Information
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001014752.1NP_001014752.1NC_004354.3 range: 19415961..19424936
NM_001014753.1NP_001014753.1NC_004354.3 range: 19415961..19424936
NM_001014754.1NP_001014754.1NC_004354.3 range: 19415961..19424936
NM_001014755.1NP_001014755.1NC_004354.3 range: 19415961..19424936
NM_001014756.1NP_001014756.1NC_004354.3 range: 19415961..19424936
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIDA (15306652)
GO:0005634nucleusCellular ComponentISS
GO:0003677DNA bindingMolecular FunctionIEA
GO:0003682chromatin bindingMolecular FunctionIDA (15306652)
GO:0003714transcription corepressor activityMolecular FunctionIDA (15306652)
GO:0005515protein bindingMolecular FunctionIPI (15306652|16763555)
GO:0016564transcription repressor activityMolecular FunctionISS
GO:0045892negative regulation of transcription, DNA-dependentBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:32941