ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

mal

Alias:

5|CG1692|bz|ma-l

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

19D1-19D1

Physical Location:

20300707-20304236 on NC_004354.3

Gene Type:

protein-coding

Human Ortholog:

GeneID: 55034 Symbol (Name): MOCOS (molybdenum cofactor sulfurase)

Ortholog Status:

The human GeneID 55034 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		mal
P Value:		3.10E-02
Note:		Slow up-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_078699.2	NP_523423.1	NC_004354.3 range: 20300707..20304236

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005575	cellular_component	Cellular Component	ND
GO:0008265	Mo-molybdopterin cofactor sulfurase activity	Molecular Function	IMP (11029694)
GO:0008265	Mo-molybdopterin cofactor sulfurase activity	Molecular Function	NAS
GO:0030151	molybdenum ion binding	Molecular Function	IEA
GO:0030170	pyridoxal phosphate binding	Molecular Function	IEA
GO:0006727	ommochrome biosynthetic process	Biological Process	IMP (1909678)
GO:0006777	Mo-molybdopterin cofactor biosynthetic process	Biological Process	NAS
GO:0043545	molybdopterin cofactor metabolic process	Biological Process	IMP (11029694)