ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

HSPA2

Full Name:

heat shock 70kDa protein 2

Alias:

HSP70-2|HSP70-3

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

14q24.1

Physical Location:

64076938-64079707 on NC_000014.7

Gene Type:

protein-coding

Orthologs:

This gene has Rat: 60460 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		L26336
Fold Change:		-3, -1.6
Note:		Differential expression on the oligonucleotide array (two fold changes are from two case groups)

Dataset Information

Name:		11141048
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:		RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_021979.3	NP_068814.2	NC_000014.7 range: 64076938..64079707

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0009986	cell surface	Cellular Component	IEP (12493773)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0051082	unfolded protein binding	Molecular Function	TAS (3037489)
GO:0006986	response to unfolded protein	Biological Process	TAS (7829106)
GO:0007140	male meiosis	Biological Process	TAS (8622925)
GO:0007286	spermatid development	Biological Process	TAS (8622925)