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Gene Information
Gene ID:60460
Symbol:Hspa2
Full Name:heat shock protein 2
Alias:Hspt70|Hst70|MGC93458
Organism:Rattus norvegicus (Rat)
Chromosome:6
Genetic Location:6q24
Physical Location:99000304-99003040 on NC_005105.2
Gene Type:protein-coding
Human Ortholog:GeneID: 3306    Symbol (Name): HSPA2 (heat shock 70kDa protein 2)
Ortholog Status:The human GeneID 3306 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Rn.44325
Original ID2:Hspt70
Fold Change:1.25
P Value:0.00779
Note:higher levels in hippocampus of iP than iNP rats
Dataset Information
Name:15660665
Method:Microarray
Tissue:Hippocampus
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).
Gene Information
Original ID1:Hspa2
Fold Change:1.24
Tissue:Caudate-putamen
Dataset Information
Name:17517326
Method:Microarray
Tissue:Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed
Summary:The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_021863.3NP_068635.1NC_005105.2 range: 99000304..99003040
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005739mitochondrionCellular ComponentIEA
GO:0005739mitochondrionCellular ComponentISS
GO:0009986cell surfaceCellular ComponentISS
GO:0009986cell surfaceCellular ComponentIEA
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionISS
GO:0005524ATP bindingMolecular FunctionIEA
GO:0007283spermatogenesisBiological ProcessIEA
GO:0007275multicellular organismal developmentBiological ProcessIEA
GO:0006950response to stressBiological ProcessIEA
GO:0030154cell differentiationBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:60460
RGD:620664
Ensembl:ENSRNOG00000006472
dbSNP:Hspa2