Gene Information |
Gene ID: | | 60460 |
Symbol: | | Hspa2 |
Full Name: | | heat shock protein 2 |
Alias: | | Hspt70|Hst70|MGC93458 |
Organism: | | Rattus norvegicus (Rat) |
Chromosome: | | 6 |
Genetic Location: | | 6q24 |
Physical Location: | | 99000304-99003040 on NC_005105.2 |
Gene Type: | | protein-coding |
Human Ortholog: | | GeneID: 3306 Symbol (Name): HSPA2 (heat shock 70kDa protein 2) |
Ortholog Status: | | The human GeneID 3306 is also in human dataset(s). |
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Gene in Ethanol Study Datasets |
Gene Information | Original ID1: | | Rn.44325 | Original ID2: | | Hspt70 | Fold Change: | | 1.25 | P Value: | | 0.00779 | Note: | | higher levels in hippocampus of iP than iNP rats |
| Dataset Information | Name: | | 15660665 | Method: | | Microarray | Tissue: | | Hippocampus | Phenotype: | | Alcohol-preferring, alcohol-nonpreferring | Publication: | | Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed | Summary: | | The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01). |
| Gene Information | Original ID1: | | Hspa2 | Fold Change: | | 1.24 | Tissue: | | Caudate-putamen |
| Dataset Information | Name: | | 17517326 | Method: | | Microarray | Tissue: | | Nucleus accumbens, amygdala, frontal cortex, caudate-putamen, and hippocampus | Phenotype: | | Alcohol-preferring, alcohol-nonpreferring | Publication: | | Kimpel et al. Alcohol. (2007) Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions. PubMed | Summary: | | The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. Gene expression was determined in the nucleus accumbens (ACB), amygdala (AMYG), frontal cortex (FC), caudate-putamen (CPU), and hippocampus (HIPP) of alcohol-naive adult male iP and iNP rats, using Affymetrix Rat Genome U34A microarrays (n = 6/strain). Using Linear Modeling for Microarray Analysis with a false discovery rate threshold of 0.1, there were 16 genes with differential expression in the ACB, 54 in the AMYG, 8 in the FC, 24 in the CPU, and 21 in the HIPP. All the fold change are iP vs. iNP fold change. |
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Gene Refseq Sequence Annotation |
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Gene Ontology (GO) Annotation |
GO ID | GO Term | Category | Evidence (PubMed) | |
GO:0005739 | mitochondrion | Cellular Component | IEA | |
GO:0005739 | mitochondrion | Cellular Component | ISS | |
GO:0009986 | cell surface | Cellular Component | ISS | |
GO:0009986 | cell surface | Cellular Component | IEA | |
GO:0000166 | nucleotide binding | Molecular Function | IEA | |
GO:0005515 | protein binding | Molecular Function | IEA | |
GO:0005515 | protein binding | Molecular Function | ISS | |
GO:0005524 | ATP binding | Molecular Function | IEA | |
GO:0007283 | spermatogenesis | Biological Process | IEA | |
GO:0007275 | multicellular organismal development | Biological Process | IEA | |
GO:0006950 | response to stress | Biological Process | IEA | |
GO:0030154 | cell differentiation | Biological Process | IEA | |
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Other Database Cross Links |
NCBI Entrez Gene: | | 60460 |
RGD: | | 620664 |
Ensembl: | | ENSRNOG00000006472 |
dbSNP: | | Hspa2 |