ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CG1718

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

19F3-19F3

Physical Location:

21163740-21171388 on NC_004354.3, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 21 Symbol (Name): ABCA3 (ATP-binding cassette, sub-family A (ABC1), member 3)

Ortholog Status:

The human GeneID 21 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		CG1718
P Value:		2.02E-02
Note:		Acute down-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_134601.1	NP_608445.1	NC_004354.3 range: 21163740..21171388, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0043190	ATP-binding cassette (ABC) transporter complex	Cellular Component	ISS
GO:0005215	transporter activity	Molecular Function	ISS
GO:0005524	ATP binding	Molecular Function	IEA
GO:0042626	ATPase activity, coupled to transmembrane movement of substances	Molecular Function	ISS