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Gene Information
Gene ID:33114
Organism:Drosophila melanogaster (Fly)
Genetic Location:19F5-19F5
Physical Location:21229302-21232713 on NC_004354.3
Gene Type:protein-coding
Human Ortholog:GeneID: 4735    Symbol (Name): SEPT2 (septin 2)
Ortholog Status:The human GeneID 4735 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Sep1
P Value:3.38E-03
Note:Slow up-regulation, have human and mouse orthologs.
Dataset Information
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_078706.2NP_523430.1NC_004354.3 range: 21229302..21232713
NM_167747.1NP_728418.1NC_004354.3 range: 21229302..21232713
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0045172germline ring canalCellular ComponentNAS (11131529)
GO:0031105septin complexCellular ComponentIEA
GO:0005940septin ringCellular ComponentISS (10908588)
GO:0005515protein bindingMolecular FunctionIPI (11884525)
GO:0005525GTP bindingMolecular FunctionISS
GO:0003924GTPase activityMolecular FunctionNAS
GO:0007049cell cycleBiological ProcessIEA
GO:0007349cellularizationBiological ProcessTAS (12386932)
GO:0000910cytokinesisBiological ProcessNAS
GO:0000910cytokinesisBiological ProcessISS (10908588)
Other Database Cross Links
NCBI Entrez Gene:33114