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Gene Information
Gene ID:33132
Symbol:CG14619
Organism:Drosophila melanogaster (Fly)
Chromosome:X
Genetic Location:20B1-20B3
Physical Location:21857638-21870326 on NC_004354.3
Gene Type:protein-coding
Human Ortholog:GeneID: 9099    Symbol (Name): USP2 (ubiquitin specific peptidase 2)
Ortholog Status:The human GeneID 9099 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:CG14619
P Value:2.48E-02
Note:Slow up-regulation, have human and mouse orthologs.
Dataset Information
Name:17054780
Method:Microarray
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_134618.2NP_608462.1NC_004354.3 range: 21857638..21870326
NM_167775.1NP_728453.1NC_004354.3 range: 21857638..21870326
NM_167776.1NP_728454.1NC_004354.3 range: 21857638..21870326
NM_167777.1NP_728455.1NC_004354.3 range: 21857638..21870326
NM_167778.1NP_728456.1NC_004354.3 range: 21857638..21870326
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0004221ubiquitin thiolesterase activityMolecular FunctionIEA
GO:0004843ubiquitin-specific protease activityMolecular FunctionTAS
GO:0006511ubiquitin-dependent protein catabolic processBiological ProcessIEA
GO:0016579protein deubiquitinationBiological ProcessTAS
Other Database Cross Links
NCBI Entrez Gene:33132
FLYBASE:FBgn0031187