ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

cbt

Alias:

CG4427|EP(2)2237|EP2237|dTIEG

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

21D1-21D1

Physical Location:

476436-479681 on NT_033779.4, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 8462 Symbol (Name): KLF11 (Kruppel-like factor 11)

Ortholog Status:

The human GeneID 8462 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		cbt
P Value:		1.44E-04
Note:		Acute up-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005622	intracellular	Cellular Component	IEA
GO:0003676	nucleic acid binding	Molecular Function	IEA
GO:0016563	transcription activator activity	Molecular Function	ISS
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0001736	establishment of planar polarity	Biological Process	NAS
GO:0048102	autophagic cell death	Biological Process	IEP (12593804)
GO:0045941	positive regulation of transcription	Biological Process	ISS
GO:0035071	salivary gland cell autophagic cell death	Biological Process	IEP (12593804)
GO:0007423	sensory organ development	Biological Process	IMP (10835395)
GO:0007391	dorsal closure	Biological Process	NAS
GO:0007391	dorsal closure	Biological Process	IMP (16198331)
GO:0007390	germ-band shortening	Biological Process	NAS
GO:0007254	JNK cascade	Biological Process	NAS
GO:0048592	eye morphogenesis	Biological Process	NAS