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Gene Information
Gene ID:33224
Organism:Drosophila melanogaster (Fly)
Genetic Location:21D1-21D1
Physical Location:476436-479681 on NT_033779.4, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 8462    Symbol (Name): KLF11 (Kruppel-like factor 11)
Ortholog Status:The human GeneID 8462 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:cbt
P Value:1.44E-04
Note:Acute up-regulation, have human and mouse orthologs.
Dataset Information
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_134685.2NP_608529.2NT_033779.4 range: 476436..479681, complement
NM_164384.1NP_722636.1NT_033779.4 range: 476436..479681, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005622intracellularCellular ComponentIEA
GO:0003676nucleic acid bindingMolecular FunctionIEA
GO:0016563transcription activator activityMolecular FunctionISS
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0001736establishment of planar polarityBiological ProcessNAS
GO:0048102autophagic cell deathBiological ProcessIEP (12593804)
GO:0045941positive regulation of transcriptionBiological ProcessISS
GO:0035071salivary gland cell autophagic cell deathBiological ProcessIEP (12593804)
GO:0007423sensory organ developmentBiological ProcessIMP (10835395)
GO:0007391dorsal closureBiological ProcessNAS
GO:0007391dorsal closureBiological ProcessIMP (16198331)
GO:0007390germ-band shorteningBiological ProcessNAS
GO:0007254JNK cascadeBiological ProcessNAS
GO:0048592eye morphogenesisBiological ProcessNAS
Other Database Cross Links
NCBI Entrez Gene:33224