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Gene Information
Gene ID:33265
Organism:Drosophila melanogaster (Fly)
Genetic Location:21E2-21E2
Physical Location:852766-854538 on NT_033779.4
Gene Type:protein-coding
Human Ortholog:GeneID: 253190    Symbol (Name): SERHL2 (serine hydrolase-like 2)
Ortholog Status:The human GeneID 253190 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:kraken
P Value:3.19E-02
Note:Acute up-regulation, have human orthologs
Dataset Information
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_057917.3NP_477265.1NT_033779.4 range: 852766..854538
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005575cellular_componentCellular ComponentND
GO:0016787hydrolase activityMolecular FunctionIEA
GO:0017171serine hydrolase activityMolecular FunctionNAS (9831651)
GO:0007586digestionBiological ProcessIEP (9831651)
GO:0009636response to toxinBiological ProcessIEP (9831651)
Other Database Cross Links
NCBI Entrez Gene:33265