ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

cpb

Alias:

CG17158|CP|CP-beta|CapZ|J|bnd

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

22B1-22B1

Physical Location:

1704903-1706961 on NT_033779.4

Gene Type:

protein-coding

Human Ortholog:

GeneID: 832 Symbol (Name): CAPZB (capping protein (actin filament) muscle Z-line, beta)

Ortholog Status:

The human GeneID 832 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		cpb
P Value:		1.35E-02
Note:		Acute up-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_057657.4	NP_477005.1	NT_033779.4 range: 1704903..1706961

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0008290	F-actin capping protein complex	Cellular Component	ISS
GO:0008290	F-actin capping protein complex	Cellular Component	NAS
GO:0003779	actin binding	Molecular Function	ISS (10908588)
GO:0007015	actin filament organization	Biological Process	IMP (14527345)
GO:0030036	actin cytoskeleton organization and biogenesis	Biological Process	IMP (16143599)
GO:0030832	regulation of actin filament length	Biological Process	IMP (12975351)
GO:0035220	wing disc development	Biological Process	IMP (16887822)
GO:0051016	barbed-end actin filament capping	Biological Process	IDA (8682865)