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Gene Information
Gene ID:33346
Organism:Drosophila melanogaster (Fly)
Genetic Location:22B1-22B1
Physical Location:1704903-1706961 on NT_033779.4
Gene Type:protein-coding
Human Ortholog:GeneID: 832    Symbol (Name): CAPZB (capping protein (actin filament) muscle Z-line, beta)
Ortholog Status:The human GeneID 832 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:cpb
P Value:1.35E-02
Note:Acute up-regulation, have human and mouse orthologs.
Dataset Information
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_057657.4NP_477005.1NT_033779.4 range: 1704903..1706961
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0008290F-actin capping protein complexCellular ComponentISS
GO:0008290F-actin capping protein complexCellular ComponentNAS
GO:0003779actin bindingMolecular FunctionISS (10908588)
GO:0007015actin filament organizationBiological ProcessIMP (14527345)
GO:0030036actin cytoskeleton organization and biogenesisBiological ProcessIMP (16143599)
GO:0030832regulation of actin filament lengthBiological ProcessIMP (12975351)
GO:0035220wing disc developmentBiological ProcessIMP (16887822)
GO:0051016barbed-end actin filament cappingBiological ProcessIDA (8682865)
Other Database Cross Links
NCBI Entrez Gene:33346