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Gene Information
Gene ID:33354
Organism:Drosophila melanogaster (Fly)
Genetic Location:22B1-22B2
Physical Location:1732525-1750612 on NT_033779.4
Gene Type:protein-coding
Human Ortholog:This gene has no human ortholog.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:CG17646
P Value:2.08E-02
Note:Transient up-regulation
Dataset Information
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_134774.2NP_608618.1NT_033779.4 range: 1732525..1750612
NM_164436.1NP_722727.1NT_033779.4 range: 1732525..1750612
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0043190ATP-binding cassette (ABC) transporter complexCellular ComponentISS
GO:0005215transporter activityMolecular FunctionISS
GO:0005524ATP bindingMolecular FunctionIEA
GO:0042626ATPase activity, coupled to transmembrane movement of substancesMolecular FunctionISS
Other Database Cross Links
NCBI Entrez Gene:33354