ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Ddr

Alias:

CG11573|CG13984|CG13985|CG33531|CG9488|CG9490|CT33540|Dmel_CG13984

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

26C1-26C2

Physical Location:

6272816-6322250 on NT_033779.4

Gene Type:

protein-coding

Human Ortholog:

GeneID: 4921 Symbol (Name): DDR2 (discoidin domain receptor tyrosine kinase 2)

Ortholog Status:

The human GeneID 4921 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001014474.2	NP_001014474.2	NT_033779.4 range: 6272816..6322250

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	ISS
GO:0004713	protein-tyrosine kinase activity	Molecular Function	NAS (10908587)
GO:0004714	transmembrane receptor protein tyrosine kinase activity	Molecular Function	ISS
GO:0006468	protein amino acid phosphorylation	Biological Process	NAS (10908587)
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	Biological Process	ISS