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Gene Information
Gene ID:3346209
Organism:Drosophila melanogaster (Fly)
Genetic Location:26C1-26C2
Physical Location:6272816-6322250 on NT_033779.4
Gene Type:protein-coding
Human Ortholog:GeneID: 4921    Symbol (Name): DDR2 (discoidin domain receptor tyrosine kinase 2)
Ortholog Status:The human GeneID 4921 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Ddr
P Value:9.33E-03
Note:Slow up-regulation
Dataset Information
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001014474.2NP_001014474.2NT_033779.4 range: 6272816..6322250
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016021integral to membraneCellular ComponentISS
GO:0004713protein-tyrosine kinase activityMolecular FunctionNAS (10908587)
GO:0004714transmembrane receptor protein tyrosine kinase activityMolecular FunctionISS
GO:0006468protein amino acid phosphorylationBiological ProcessNAS (10908587)
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:3346209