ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Duox

Alias:

CG3131|dDuox

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

23B2-23B2

Physical Location:

2816005-2821304 on NT_033779.4, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 53905 Symbol (Name): DUOX1 (dual oxidase 1)

Ortholog Status:

The human GeneID 53905 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		CG3131
P Value:		1.11E-02
Note:		Slow up-regulation, have human orthologs

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_134871.1	NP_608715.1	NT_033779.4 range: 2816005..2821304, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0004601	peroxidase activity	Molecular Function	IDA (16272120)
GO:0005506	iron ion binding	Molecular Function	IEA
GO:0005509	calcium ion binding	Molecular Function	IEA
GO:0016175	superoxide-generating NADPH oxidase activity	Molecular Function	ISS
GO:0020037	heme binding	Molecular Function	IEA
GO:0050660	FAD binding	Molecular Function	IEA
GO:0006979	response to oxidative stress	Biological Process	IEA
GO:0042742	defense response to bacterium	Biological Process	IMP (16272120)