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Gene Information
Gene ID:33477
Organism:Drosophila melanogaster (Fly)
Genetic Location:23B2-23B2
Physical Location:2816005-2821304 on NT_033779.4, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 53905    Symbol (Name): DUOX1 (dual oxidase 1)
Ortholog Status:The human GeneID 53905 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:CG3131
P Value:1.11E-02
Note:Slow up-regulation, have human orthologs
Dataset Information
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_134871.1NP_608715.1NT_033779.4 range: 2816005..2821304, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016021integral to membraneCellular ComponentIEA
GO:0004601peroxidase activityMolecular FunctionIDA (16272120)
GO:0005506iron ion bindingMolecular FunctionIEA
GO:0005509calcium ion bindingMolecular FunctionIEA
GO:0016175superoxide-generating NADPH oxidase activityMolecular FunctionISS
GO:0020037heme bindingMolecular FunctionIEA
GO:0050660FAD bindingMolecular FunctionIEA
GO:0006979response to oxidative stressBiological ProcessIEA
GO:0042742defense response to bacteriumBiological ProcessIMP (16272120)
Other Database Cross Links
NCBI Entrez Gene:33477