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Gene Information
Gene ID:33547
Organism:Drosophila melanogaster (Fly)
Genetic Location:23E4-23E4
Physical Location:3330952-3332877 on NT_033779.4
Gene Type:protein-coding
Human Ortholog:This gene has no human ortholog.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:CG3285
P Value:2.21E-02
Note:Slow up-regulation
Dataset Information
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_134922.2NP_608766.1NT_033779.4 range: 3330952..3332877
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016021integral to membraneCellular ComponentIEA
GO:0003677DNA bindingMolecular FunctionIEA
GO:0005351sugar:hydrogen symporter activityMolecular FunctionIEA
GO:0008170N-methyltransferase activityMolecular FunctionIEA
GO:0006306DNA methylationBiological ProcessIEA
GO:0008643carbohydrate transportBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:33547