ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CG40045

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Physical Location:

24021620-24028959 on NT_037436.3

Gene Type:

protein-coding

Human Ortholog:

GeneID: 7326 Symbol (Name): UBE2G1 (ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast))

Ortholog Status:

The human GeneID 7326 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_001043175.1	NP_001036640.1	NT_037436.3 range: 24021620..24028959

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0019787	small conjugating protein ligase activity	Molecular Function	IEA
GO:0043687	post-translational protein modification	Biological Process	IEA
GO:0051246	regulation of protein metabolic process	Biological Process	IEA