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Gene Information
Gene ID:33569
Alias:153432_at|4E-BP|4E-BP1|4EBP|BcDNA.HL08053|BcDNA:HL08053|CG8846|CT8705|Dm 4E-BP|Phas1|anon-WO0172774.158|d4E-BP|d4E-BP1|d4EBP|eIF4E-BP|l(2)k07736|l(2)k13517|pp20
Organism:Drosophila melanogaster (Fly)
Genetic Location:23F3-23F3
Physical Location:3478433-3479620 on NT_033779.4
Gene Type:protein-coding
Human Ortholog:GeneID: 1979    Symbol (Name): EIF4EBP2 (eukaryotic translation initiation factor 4E binding protein 2)
Ortholog Status:The human GeneID 1979 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Thor
P Value:2.93E-03
Note:Transient up-regulation
Dataset Information
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_057947.3NP_477295.1NT_033779.4 range: 3478433..3479620
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0008190eukaryotic initiation factor 4E bindingMolecular FunctionNAS
GO:0008190eukaryotic initiation factor 4E bindingMolecular FunctionISS (10471706|10811906)
GO:0008190eukaryotic initiation factor 4E bindingMolecular FunctionIDA (11389445)
GO:0001558regulation of cell growthBiological ProcessIGI (11389445)
GO:0045792negative regulation of cell sizeBiological ProcessTAS (12563289)
GO:0042594response to starvationBiological ProcessIMP (16055649)
GO:0019731antibacterial humoral responseBiological ProcessIMP (10811906)
GO:0006979response to oxidative stressBiological ProcessIMP (16055649)
GO:0006955immune responseBiological ProcessNAS
GO:0006955immune responseBiological ProcessIMP (10811906)
GO:0006955immune responseBiological ProcessIEP (10811906)
GO:0006952defense responseBiological ProcessNAS
GO:0006950response to stressBiological ProcessIEP (12908874)
GO:0006641triacylglycerol metabolic processBiological ProcessIMP (16103212)
GO:0001558regulation of cell growthBiological ProcessIMP (11389445)
GO:0045947negative regulation of translational initiationBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:33569