ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Thor

Alias:

153432_at|4E-BP|4E-BP1|4EBP|BcDNA.HL08053|BcDNA:HL08053|CG8846|CT8705|Dm 4E-BP|Phas1|anon-WO0172774.158|d4E-BP|d4E-BP1|d4EBP|eIF4E-BP|l(2)k07736|l(2)k13517|pp20

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

23F3-23F3

Physical Location:

3478433-3479620 on NT_033779.4

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1979 Symbol (Name): EIF4EBP2 (eukaryotic translation initiation factor 4E binding protein 2)

Ortholog Status:

The human GeneID 1979 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Thor
P Value:		2.93E-03
Note:		Transient up-regulation

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_057947.3	NP_477295.1	NT_033779.4 range: 3478433..3479620

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0008190	eukaryotic initiation factor 4E binding	Molecular Function	NAS
GO:0008190	eukaryotic initiation factor 4E binding	Molecular Function	ISS (10471706\|10811906)
GO:0008190	eukaryotic initiation factor 4E binding	Molecular Function	IDA (11389445)
GO:0001558	regulation of cell growth	Biological Process	IGI (11389445)
GO:0045792	negative regulation of cell size	Biological Process	TAS (12563289)
GO:0042594	response to starvation	Biological Process	IMP (16055649)
GO:0019731	antibacterial humoral response	Biological Process	IMP (10811906)
GO:0006979	response to oxidative stress	Biological Process	IMP (16055649)
GO:0006955	immune response	Biological Process	NAS
GO:0006955	immune response	Biological Process	IMP (10811906)
GO:0006955	immune response	Biological Process	IEP (10811906)
GO:0006952	defense response	Biological Process	NAS
GO:0006950	response to stress	Biological Process	IEP (12908874)
GO:0006641	triacylglycerol metabolic process	Biological Process	IMP (16103212)
GO:0001558	regulation of cell growth	Biological Process	IMP (11389445)
GO:0045947	negative regulation of translational initiation	Biological Process	IEA