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Gene Information
Gene ID:33583
Organism:Drosophila melanogaster (Fly)
Genetic Location:24A1-24A1
Physical Location:3604221-3606747 on NT_033779.4, complement
Gene Type:protein-coding
Human Ortholog:This gene has no human ortholog.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:odd
P Value:1.30E-02
Note:Transient down-regulation
Dataset Information
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_164546.1NP_722922.1NT_033779.4 range: 3604221..3606747, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005622intracellularCellular ComponentIEA
GO:0005634nucleusCellular ComponentISS (2120051)
GO:0005634nucleusCellular ComponentNAS
GO:0003676nucleic acid bindingMolecular FunctionIEA
GO:0003704specific RNA polymerase II transcription factor activityMolecular FunctionISS (2120051)
GO:0008270zinc ion bindingMolecular FunctionIEA
GO:0006357regulation of transcription from RNA polymerase II promoterBiological ProcessISS (2120051)
GO:0007366periodic partitioning by pair rule geneBiological ProcessNAS
GO:0016348imaginal disc-derived leg joint morphogenesisBiological ProcessIMP (14597202)
Other Database Cross Links
NCBI Entrez Gene:33583