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Gene Information
Gene ID:3359
Symbol:HTR3A
Full Name:5-hydroxytryptamine (serotonin) receptor 3A
Alias:5-HT-3|5-HT3A|5-HT3R|5HT3R|HTR3
Organism:Homo sapiens (Human)
Chromosome:11
Genetic Location:11q23.1
Physical Location:113351119-113366244 on NC_000011.8
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:HTR3A
Dataset Information
Name:18477577
Method:Addiction array gene list
Publication:Hodgkinson et al. Alcohol Alcohol. (2008) Addictions Biology: Haplotype-Based Analysis for 130 Candidate Genes on a Single Array. PubMed
Summary:To develop a panel of markers able to extract full haplotype information for candidate genes in alcoholism, other addictions and disorders of mood and anxiety. Methods: A total of 130 genes were haplotype tagged and genotyped in 7 case/control populations and 51 reference populations using Illumina GoldenGate SNP genotyping technology, determining haplotype coverage. The 130 candidate genes were selected on the basis of their roles in functional domains important in the addictions and in the related phenotypes of anxiety and depression. The candidate genes included a limited number involved in the pharmacokinetic domain (e.g. several genes in the ADH gene cluster, and ALDH genes). The majority of the genes represent the domains of vulnerability to drug use and pharmacodynamic response. These include dopamine, serotonin, glutamine, GABA, and opioid neurotransmitter genes, signaling genes, and genes modulating stress resiliency and behavioral dyscontrol domains. There is a high degree of overlap between functional gene categories because of pleiotropic actions of molecules on behavior.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_000869.2NP_000860.1NC_000011.8 range: 113351119..113366244
NM_213621.1NP_998786.1NC_000011.8 range: 113351119..113366244
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0045211postsynaptic membraneCellular ComponentIEA
GO:0045202synapseCellular ComponentIEA
GO:0030054cell junctionCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIEA
GO:0005886plasma membraneCellular ComponentIEA
GO:0005887integral to plasma membraneCellular ComponentTAS (7565620)
GO:0030594neurotransmitter receptor activityMolecular FunctionIEA
GO:0004993serotonin receptor activityMolecular FunctionNAS
GO:0005232serotonin-activated cation-selective channel activityMolecular FunctionTAS (7565620)
GO:0005230extracellular ligand-gated ion channel activityMolecular FunctionNAS
GO:0005230extracellular ligand-gated ion channel activityMolecular FunctionIEA
GO:0005216ion channel activityMolecular FunctionIEA
GO:0007268synaptic transmissionBiological ProcessTAS (7565620)
GO:0007586digestionBiological ProcessTAS (7565620)
GO:0006811ion transportBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:3359
HGNC:5297
Ensembl:ENSG00000166736
MIM:182139
HPRD:08917
HuGE Navigator:3359
dbSNP:HTR3A
GeneCard:HTR3A
AceView:HTR3A