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Gene Information
Gene ID:33754
Organism:Drosophila melanogaster (Fly)
Genetic Location:25D2-25D2
Physical Location:5264000-5265898 on NT_033779.4
Gene Type:protein-coding
Human Ortholog:This gene has no human ortholog.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Cyp4ac1
P Value:3.51E-02
Note:Slow down-regulation
Dataset Information
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_135072.2NP_608916.1NT_033779.4 range: 5264000..5265898
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005792microsomeCellular ComponentNAS
GO:0016020membraneCellular ComponentNAS
GO:0004497monooxygenase activityMolecular FunctionIEA
GO:0005506iron ion bindingMolecular FunctionIEA
GO:0009055electron carrier activityMolecular FunctionISS
GO:0009055electron carrier activityMolecular FunctionNAS
GO:0020037heme bindingMolecular FunctionIEA
GO:0042445hormone metabolic processBiological ProcessNAS
GO:0046701insecticide catabolic processBiological ProcessNAS
Other Database Cross Links
NCBI Entrez Gene:33754