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Gene Information
Gene ID:33812
Organism:Drosophila melanogaster (Fly)
Genetic Location:26A1-26A1
Physical Location:5824841-5856756 on NT_033779.4
Gene Type:protein-coding
Human Ortholog:This gene has no human ortholog.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:CG14004
P Value:1.07E-02
Note:Slow up-regulation
Dataset Information
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001103622.1NP_001097092.1NT_033779.4 range: 5824841..5856756
NM_135118.2NP_608962.2NT_033779.4 range: 5824841..5856756
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016021integral to membraneCellular ComponentISS (10908591|11381038)
GO:0004930G-protein coupled receptor activityMolecular FunctionISS
GO:0008188neuropeptide receptor activityMolecular FunctionISS (11381038)
GO:0008528peptide receptor activity, G-protein coupledMolecular FunctionISS (10908591)
GO:0007186G-protein coupled receptor protein signaling pathwayBiological ProcessISS (10908591|11381038)
Other Database Cross Links
NCBI Entrez Gene:33812